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Porphyrins, Fractionated, Quantitative, 24-Hour Urine
Test Code729
CPT Codes
84120
Includes
Coproporphyrin I, Coproporphyrin III, Heptacarboxyporphyrin, Hexacarboxyporphyrin, Pentacarboxyporphyrin, Total Porphyrins, Uroporphyrin I, Uroporphyrin III
CPT code 81050 may be added at an additional charge for volume measurement
Preferred Specimen
2 mL of a preserved 24-hour urine, submitted in a plastic, leak-proof container
Minimum Volume
1 mL
Other Acceptable Specimens
Unpreserved 24-hour urine, submitted in a plastic, leak-proof container
Instructions
Protect sample from light: 2 mL 24-hour urine in 5 grams sodium carbonate (Na2CO3) container or no preservative container.
24-hour urine collected with 5 grams of sodium carbonate, refrigerated, and protected from light during collection is preferred. Collection with no preservative is acceptable, if properly refrigerated and light protected. 24-hour total volume must be provided on the test request form.
Transport Container
Plastic screw-cap vial - protected from light
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: Unacceptable
Refrigerated: 7 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received room temperature • Not protected from light • pH <4.0
Methodology
High Performance Liquid Chromatography (HPLC)
Setup Schedule
Set up: Tues-Sat p.m.; Report available: 2-6 days
Reference Range
Adult Reference Ranges | |
Uroporphyrin I | 4.1-22.4 mcg/24 h |
Uroporphyrin III | 0.7-7.4 mcg/24 h |
Heptacarboxyporphyrin | ≤3.3 mcg/24 h |
Hexacarboxyporphyrin | ≤10 mcg/24 h |
Pentacarboxyporphyrin | ≤4.6 mcg/24 h |
Coproporphyrin I | 7.1-48.7 mcg/24 h |
Coproporphyrin III | 11.0-148.5 mcg/24 h |
Total Porphyrins | 35-210.7 mcg/24 h |
Clinical Significance
Porphyria is a group of distinct disorders characterized by the abnormal accumulation of porphyrins or porphyrin precursors. Porphyrin Fractionation of Urine is useful in diagnosing porphyrin cutanea tarda, hereditary coproporphyria, and variegate porphyria.
Performing Laboratory
Quest Diagnostics Nichols Inst San Juan Capistrano
33608 Ortega Highway
San Juan Capistrano, CA 92675