IgG4, IHC with Interpretation

Test Code
91315


CPT Codes
88342

Preferred Specimen
1 formalin-fixed, paraffin-embedded tissue block


Minimum Volume
1 Block


Other Acceptable Specimens
3 unstained, (+) charged slides, submitted in IHC Specimen Transport Kit


Instructions
Please include surgical pathology report.


Transport Container
IHC Specimen Transport Kit


Transport Temperature
Room temperature


Specimen Stability
Room temperature: Indefinite
Refrigerated: Indefinite
Frozen: Unacceptable


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received frozen


Methodology
Immunohistochemistry (IHC)

Setup Schedule
Setup: Mon-Fri a.m.; Report available: 3 days


Reference Range
See Laboratory Report


Clinical Significance
IgG4-related sclerosing disease is a clinicopathologically-defined immune disorder that can present in lymph node or other tissues. An increased number of IgG4+ plasma cells detected by this antibody can help establish the diagnosis, with cases showing histologic features of cutaneous pseudolymphomas and/or intra-germinal center and interfollicular plasmacytosis. Although the presence of increased numbers of IgG4+ plasma cells is not specific for this disease it can help differentiate it from inflammatory myofibroblastic tumor which typically shows absent or rare IgG4+ plasma cells.


Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153




The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.