Miller Fisher Syndrome, Cranial Neuropathy Antibody Panel (Ganglioside)

Test Code

90128

CPT Codes
83520 (x4)

Includes

Ganglioside GM-1 Antibody (IgG), EIA
Ganglioside GD1a Antibody (IgG), EIA
Ganglioside GD1b Antibody (IgG), EIA
Ganglioside GQ1b Antibody (IgG), EIA

Preferred Specimen

2 mL serum

Patient Preparation
Overnight fasting is preferred

Minimum Volume

0.8 mL

Transport Container

Transport tube

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 24 hours
Refrigerated: 7 days
Frozen: 21 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Received room temperature

Methodology
Immunoassay (IA)

Setup Schedule

Set up: Mon. , Wed. : Report Available: 4 days

Reference Range

GM-1 Ab (IgG)	<1:800 Titer
Normal	<1:800
Moderately elevated	1:800-1:3200
Highly elevated	≥1:6400
GD1a Ab (IgG)	<1:100 Titer
GD1b Ab (IgG)	<1:100 Titer
GQ1b Ab (IgG)	<1:100 Titer

Clinical Significance

Ganglioside GM-1 IgG antibody is associated with acute inflammatory demyelinating polyneuropathy and acute motor axonal neuropathy. GD1a IgG antibody may also be associated with acute motor axonal neuropathy. GD1b IgG antibody may be associated with acute motor and sensory axonal neuropathy with cerebellar ataxia or ataxic presentations of Guillain-Barré Syndrome. GQ1b IgG antibody is associated with the Miller-Fisher Syndrome.

Performing Laboratory

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA

33608 Ortega Highway

San Juan Capistrano, CA 92675-2042

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.