Miller Fisher Syndrome, Cranial Neuropathy Antibody Panel (Ganglioside)

Test Code

CPT Codes
83520 (x4)

Ganglioside GM-1 Antibody (IgG), EIA; Ganglioside GD1a Antibody (IgG), EIA; Ganglioside GD1b Antibody (IgG), EIA; Ganglioside GQ1b Antibody (IgG), EIA

Preferred Specimen
2 mL serum

Patient Preparation
Overnight fasting is preferred

Minimum Volume
0.8 mL

Transport Container
Plastic screw-cap vial

Transport Temperature
Refrigerated (cold packs)

Specimen Stability
Room temperature: 24 hours
Refrigerated: 7 days
Frozen: 21 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received room temperature

Immunoassay (IA)

Setup Schedule

Set up: Mon. , Wed. : Report Available: 4 days

Report Available
8 Days

Reference Range
GM-1 Ab (IgG) <1:800 Titer
  Normal <1:800
  Moderately elevated 1:800-1:3200
  Highly elevated ≥1:6400
GD1a Ab (IgG) <1:100 Titer
GD1b Ab (IgG) <1:100 Titer
GQ1b Ab (IgG) <1:100 Titer

Clinical Significance
Ganglioside GM-1 IgG antibody is associated with acute inflammatory demyelinating polyneuropathy and acute motor axonal neuropathy. GD1a IgG antibody may also be associated with acute motor axonal neuropathy. GD1b IgG antibody may be associated with acute motor and sensory axonal neuropathy with cerebellar ataxia or ataxic presentations of Guillain-Barré Syndrome. GQ1b IgG antibody is associated with the Miller-Fisher Syndrome.

Performing Laboratory
Quest Diagnostics Nichols Inst San Juan Capistrano 33608 Ortega Highway San Juan Capistrano, CA 92690-6130

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.