Metanephrines, Fractionated, LCMSMS, 24-Hour Urine [14962X]

Test Code

CPT Codes

Metanephrine, Normetanephrine, Total Metanephrines

CPT code 81050 may be added at an additional charge for volume measurement

Preferred Specimen
5 mL 24-hour urine with 25 mL 6N HCl collected in a 24-hour urine container

Patient Preparation
It is preferable for the patient to be off medications for three days prior to collection. Patient should avoid tobacco, tea, coffee, for three days prior to specimen collection. Common antihypertensives (diuretics, ACE inhibitors, calcium channel blockers, alpha and beta blockers) cause minimal or no interference. Medications which are alpha agonists (Aldomet), alpha blockers (Dibenzyline) should be avoided 18-24 hours prior to specimen collection.

Minimum Volume
1.5 mL

Other Acceptable Specimens
Unpreserved urine with pH <6

After urine collection, add 25 mL of 6N HCl to maintain a pH below 3. Urine without preservative is acceptable if pH is below 6 and the sample is shipped frozen. Record 24-hour urine volume on test request form and urine vial. Record patients age on test request form and urine vial.

Transport Temperature
Preserved urine: Room temperature
Unpreserved urine: Frozen

Specimen Stability
Room temperature: 7 days
Refrigerated: 8 days
Frozen: 30 days

Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule
Set up: Mon-Sat a.m.; Report available: 2 days

Reference Range
Metanephrines, 24-Hour Urine    
Age Reference Range UOM
3 months-4 years 25-117 mcg/24 h
5-9 years 11-139 mcg/24 h
10-13 years 51-275 mcg/24 h
14-17 years 40-189 mcg/24 h
18-29 years 25-222 mcg/24 h
30-39 years 36-190 mcg/24 h
40-49 years 58-203 mcg/24 h
≥50 years 90-315 mcg/24 h
Normetanephrines, 24-Hour Urine    
3 months-4 years 54-249 mcg/24 h
5-9 years 31-398 mcg/24 h
10-13 years 67-503 mcg/24 h
14-17 years 69-531 mcg/24 h
18-29 years 40-412 mcg/24 h
30-39 years 35-482 mcg/24 h
40-49 years 88-649 mcg/24 h
≥50 years 122-676 mcg/24 h
Metanephrines, Total 24-Hour Urine    
3 months-4 years 79-345 mcg/24 h
5-9 years 49-408 mcg/24 h
10-13 years 110-714 mcg/24 h
14-17 years 107-741 mcg/24 h
18-29 years 94-604 mcg/24 h
30-39 years 115-695 mcg/24 h
40-49 years 182-739 mcg/24 h
≥50 years 224-832 mcg/24 h

Clinical Significance
Test is useful in the evaluation of pheochromocytoma.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.