Mantle Cell Lymphoma, bcl-1/JH, t(11;14), Cell-Based

Test Code
14991

CPT Codes
81401

Preferred Specimen
5 mL bone marrow or whole blood collected in an EDTA (lavender-top) tube

Minimum Volume
1 mL

Other Acceptable Specimens
Formalin-fixed, paraffin-embedded tissue block

Transport Temperature
Room temperature

Specimen Stability
Bone marrow and whole blood:
Room temperature: 7 days
Refrigerated: 14 days
Frozen: Unacceptable
Tissue block:
Room temperature: Indefinitely
Refrigerated: Unacceptable
Frozen: Unacceptable

Methodology
Real-Time Polymerase Chain Reaction (RT-PCR)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule
Set up: Tues, Sat a.m.; Report available: 3 days

Reference Range
0/Negative

Clinical Significance
Bcl-1/JH t(11;14) is highly specific for mantle cell lymphoma (MCL). The t(11;14) can be found in approximately 70% to 95% cases of MCL. Half of these translocations fall within the BCL-1 major translocation cluster (MTC). The t(11;14) Real-Time PCR assay can be used to monitor minimal residual disease in NHL. Ideally, recent patient samples should be tested side by side with the previous sample to better illustrate the quantitative changes.

Performing Laboratory
Quest Diagnostics Nichols Institute San Juan Capistrano
33608 Ortega Highway
San Juan Capistrano, CA 92675



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.