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Mast Cell Tryptase, IHC without Interpretation [40017X]
Test Code40017
CPT Codes
88342-TC
Preferred Specimen
Minimum: 1 formalin-fixed, paraffin-embedded, tissue block, submitted in IHC Specimen Transport Kit, room temperature
Other Acceptable Specimens
Minimum: 3 unstained, positively charged slides, submitted in IHC Specimen Transport Kit, room temperature
Transport Container
IHC Specimen Transport Kit
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Unacceptable
Refrigerated: Indefinitely
Frozen: Unacceptable
Methodology
Immunohistochemistry
Setup Schedule
Set up: Mon-Fri a.m.; Report available: Next day
Clinical Significance
Mast cells contain a number of preformed chemical
mediators, such as histamine, chymase, carboxypeptidase,
and proteclytic tryptase. A substantial quantity of
tryptase is reported to be found in mast cells of skin
and lung and suggests this enzyme plays a major role in
mast cell mediated events; in vitro studies indicate
tryptase can cleave C3 to form C3a anaphylatoxin,
inactivate fibrinogen as a coaguable substrate for
thrombin, and activate latent collaegnase. Models of
allergenic disease in the skin, nose, and lung have
indicated elevated tryptase levels. Human mast cell
tryptase has been reported to be implicated as a mediator
of inflammation. Mast cell degranulation in the gut
causes mucus secretion, mucosal edema, increased gut
permeability, and may be responsible for some of the
symptoms and signs of inflammatory bowel disease.
mediators, such as histamine, chymase, carboxypeptidase,
and proteclytic tryptase. A substantial quantity of
tryptase is reported to be found in mast cells of skin
and lung and suggests this enzyme plays a major role in
mast cell mediated events; in vitro studies indicate
tryptase can cleave C3 to form C3a anaphylatoxin,
inactivate fibrinogen as a coaguable substrate for
thrombin, and activate latent collaegnase. Models of
allergenic disease in the skin, nose, and lung have
indicated elevated tryptase levels. Human mast cell
tryptase has been reported to be implicated as a mediator
of inflammation. Mast cell degranulation in the gut
causes mucus secretion, mucosal edema, increased gut
permeability, and may be responsible for some of the
symptoms and signs of inflammatory bowel disease.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153
