Diazepam and Metabolite

Test Code

90853

CPT Codes
80346

Includes

Diazepam, Nordiazepam, Diazepam and Nordiazepam

Preferred Specimen

2 mL serum collected in a red-top tube (no gel)

Minimum Volume

1 mL

Instructions

Collect at trough concentration, i.e., immediately before the administration of the next dose. Use polypropylene tubes and ship on cold pack by overnight courier.

Transport Container

Polypropylene tubes

Transport Temperature

Frozen

Specimen Stability

Room temperature: Unacceptable
Refrigerated: 5 days
Frozen: 14 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Serum Separator Tube (SST®)

Methodology
Calculation (CALC) • Chromatography/Mass Spectrometry

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Tues, Thurs, Sat; Report available: 3-5 days

Reference Range

Diazepam	See Laboratory Report
Nordiazepam	See Laboratory Report

Diazepam and Nordiazepam

Therapeutic	100-1500 ng/mL
Potentially toxic	>3000 ng/mL

Clinical Significance

Therapeutic drug monitoring of anxiolytic drug. Nordiazepam is the active metabolite of the parent drug. Elimination half-life is 20-90 hours.

Performing Laboratory
Quest Diagnostics Nichols Institute Valencia
27027 Tourney Road
Valencia, CA 91355-5386

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.