Yo Antibody Screen with Reflex to Titer and Western Blot, CSF

Test Code

CPT Codes

If Yo Antibody Screen, IFA, CSF is positive, then Yo Antibody, Western Blot, CSF will be performed at an additional charge (CPT code(s): 84181).
If Yo Antibody, Western Blot, CSF is positive, then Yo Antibody, Titer, CSF will be performed at an additional charge (CPT code(s): 86256).

Preferred Specimen
0.8 mL CSF

Patient Preparation
Overnight fasting is preferred

Minimum Volume
0.5 mL

Transport Container
Sterile screw-cap vial

Transport Temperature
Refrigerated (cold packs)

Specimen Stability
Room temperature: 8 hours
Refrigerated: 7 days
Frozen: 6 months

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received room temperature

Immunofluorescence Assay (IFA)

FDA Status
This test was developed and its performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. Performance characteristics refer to the analytical performance of the test.

Setup Schedule
Set up: Mon, Wed, Fri a.m; Report available: 4 days

Reference Range
Yo Ab Screen, IFA, CSFNegative
  Yo Ab, WB, CSFNegative
  Yo Ab, Titer, CSFNo Yo Antibodies detected in undiluted CSF sample

Clinical Significance
Purkinje Cell (Yo) antibody is found in approximately half of the patients with paraneoplastic cerebellar degeneration and is associated with ovarian, uterine, and small cell lung carcinomas and Hodgkin’s lymphoma.

Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA
33608 Ortega Highway
San Juan Capistrano, CA 92675-2042

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.