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Cyclosporine A Panel (Trough, 1 Hour, 2 Hour Post)
Test Code10720
CPT Codes
80158 (x3)
Preferred Specimen
2 mL (x3) whole blood collected in an EDTA (lavender-top) tube
Minimum Volume
1 mL for each specimen
Instructions
Collect 1st sample as trough, 12 hours after last dose.
Collect 2nd sample 1 hour post-dose.
Collect 3rd sample as peak, 2 hours post-dose.
Please label tubes with time collected. Transport 3 samples at room temperature in the same shipping container.
Collect 2nd sample 1 hour post-dose.
Collect 3rd sample as peak, 2 hours post-dose.
Please label tubes with time collected. Transport 3 samples at room temperature in the same shipping container.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 7 days
Frozen: 30 days
Refrigerated: 7 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Clotted specimens
Methodology
Immunoassay (IA)
Setup Schedule
Set up: Daily; Report available: 2 days
Reference Range
No definitive therapeutic or toxic ranges have been established. Opitmal blood drug levels are influenced by type of transplant, patient response, time post-transplant, co-administration of other drugs, and drug formulation.
The following trough ranges are suggested guidelines:
The following peak rarnges are suggested guidelines:
The following trough ranges are suggested guidelines:
Kidney transplantation | 100-200 mcg/L |
Other organ transplant | 200-300 mcg/L |
The following peak rarnges are suggested guidelines:
De Novo | 1500-1700 mcg/L |
<6 months | 800-1000 mcg/L |
6-12 months | 600-800 mcg/L |
>1 year | 300-600 mcg/L |
Clinical Significance
Cyclosporine (Cyclosporin A) is an immunosuppressant therapeutic agent used in the prevention of organ graft rejection. Clinical measurement of blood levels is required due to the inter-individual variability of metabolism as well as the toxicity associated with excessive dosage.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153