A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Cyclosporine A Panel (Trough, 1 Hour, 2 Hour Post)

Test Code
10720


CPT Codes
80158 (x3)

Preferred Specimen
2 mL whole blood (x3) collected in EDTA (lavender-top) tubes


Minimum Volume
1 mL for each specimen


Instructions
Collect 1st sample as trough, 12 hours after last dose.
Collect 2nd sample 1 hour post-dose.
Collect 3rd sample as peak, 2 hours post-dose.

Please label tubes with time collected. Transport 3 samples at room temperature in the same shipping container.


Transport Temperature
Room temperature


Specimen Stability
Room temperature: 7 days
Refrigerated: 7 days
Frozen: 30 days


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Clotted specimens


Methodology
Immunoassay (IA)

Setup Schedule
Set up: Daily; Report available: 2 days


Reference Range
No definitive therapeutic or toxic ranges have been established. Opitmal blood drug levels are influenced by type of transplant, patient response, time post-transplant, co-administration of other drugs, and drug formulation.

The following trough ranges are suggested guidelines:
 Kidney transplantation 100-200 mcg/L 
Other organ transplant  200-300 mcg/L 

The following peak rarnges are suggested guidelines:
De Novo 1500-1700 mcg/L
<6 months 800-1000 mcg/L
6-12 months 600-800 mcg/L
>1 year 300-600 mcg/L


Clinical Significance
Cyclosporine (Cyclosporin A) is an immunosuppressant therapeutic agent used in the prevention of organ graft rejection. Clinical measurement of blood levels is required due to the inter-individual variability of metabolism as well as the toxicity associated with excessive dosage.


Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.