Y Chromosome Microdeletion, DNA Analysis [14679Z]

Test Code
14679

CPT Codes
81403<br /> ** This test code is for non-New York patient testing. For New York patient testing, use test code 16018X**

Physician Attestation of Informed Consent
This germline genetic test requires physician attestation that patient consent has been received if ordering medical facility is located in AK, DE, FL, GA, IA, MA, MN, NV, NJ, NY, OR, SD or VT or test is performed in MA.

Preferred Specimen
4 mL whole blood collected in an EDTA (lavender-top) tube

Minimum Volume
3 mL

Other Acceptable Specimens
Whole blood collected in: ACD solution A or B (yellow-top), EDTA (royal blue-top), sodium heparin (green-top) or lithium heparin (green-top)

Instructions
Whole blood (preferred): Specimen stability is crucial. Store and ship room temperature immediately. Do not freeze.
Extracted DNA: Please call 866-GENE-INFO (866-436-3463) for additional information.

Transport Temperature
Room temperature

Specimen Stability
Room temperature: 8 days
Refrigerated: 8 days
Frozen: Unacceptable

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received frozen

Methodology
Agarose Gel Electrophoresis • Polymerase Chain Reaction (PCR)

FDA Status
This test was performed using a kit that has not been cleared or approved by the FDA. The analytical performance characteristics of this test have been determined by Quest Diagnostics. This test should not be used for diagnosis without confirmation by other medically established means.

Setup Schedule
Set up: Mon, Wed, Fri a.m.; Report available: 3 days

Limitations
The lack of detection of a deletion does not eliminate the possibility of DNA changes in other parts of the Y chromosome or other causes of infertility. This test detects the presence of a deletion in the AZF region of Yq. The presence of a deletion is consistent with a clinical indication of infertility. The lack of a deletion does not eliminate the possibility of DNA changes in other parts of the Y chromosome or other causes of infertility.

Reference Range
See Laboratory Report

Clinical Significance
To detect Y chromosome microdeletions associated with oligospermia and azoospermia. About 15-20% of azoospermic men and about 10% of severely oligospermic men present with microdeletions of Yq. This test targets 20 genetic loci, including those recommended by the European Quality Monitoring Network Group (Int J Andr 22: 292-299 (1999).

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.