Methylmalonic Acid, GC/MS/MS, Urine

Test Code

CPT Codes
82570, 83921


Preferred Specimen
1.7 mL of an unpreserved random urine submitted in a plastic leak-proof container

Minimum Volume
0.6 mL

Other Acceptable Specimens
Unpreserved, catheterized urine, or first void clean catch urine, or random clean catch urine or 24-hour urine

Do not use preservatives

Transport Temperature
Refrigerated (cold packs)

Specimen Stability
Room temperature: 4 days
Refrigerated: 12 days
Frozen (-20° C): 30 days
Frozen (-70° C): 90 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received room temperature • Acidified urine

Gas Chromatography/Tandem Mass Spectrometry (GC/MS/MS)

Setup Schedule
Set up: Tues, Fri; Report available: 4 days

Reference Range
Methylmalonic Acid, Urine 0.3-2.2 mmol/mol creat
Creatinine, Random Urine
0-6 Months 0.18-2.48 mmol/L 
7-11 Months 0.18-2.74 mmol/L
1-2 Years 0.18-9.72 mmol/L
3-8 Years 0.18-11.49 mmol/L
9-12 Years 0.18-14.14 mmol/L
>12 Years 1.77-23.31 mmol/L

Clinical Significance
Methylmalonic Acid (MMA) is useful to diagnose and monitor Vitamin B12 (cobalamin) deficiency, and to diagnose and monitor patients with methylmalonic acidemia.

Performing Laboratory
Quest Diagnostics Nichols Institute San Juan Capistrano
33608 Ortega Highway
San Juan Capistrano, CA 92675

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.