|
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Wilms Tumor 1 (WT1) Mutation Analysis
Test Code16896
CPT Codes
81405
Physician Attestation of Informed Consent
This germline genetic test requires physician attestation that patient consent has been received if ordering medical facility is located in AK, DE, FL, GA, IA, MA, MN, NV, NJ, NY, OR, SD or VT or test is performed in MA.
Preferred Specimen
6 mL whole blood collected in an EDTA (lavender-top) tube
Minimum Volume
3 mL whole blood • 1 mL bone marrow
Other Acceptable Specimens
Bone marrow collected in: EDTA (lavender-top) tube
Instructions
Whole blood: Follow standard whole blood collection procedure. Collect 5-6 mL whole blood samples in an EDTA tube. Blood samples are shipped at room temperature or 4° C. Do not freeze whole blood.
Record the draw time; also record sample type on the tube and patient ID on the test requisition. Ship immediately to maintain sample stability.
Record the draw time; also record sample type on the tube and patient ID on the test requisition. Ship immediately to maintain sample stability.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: Unacceptable
Refrigerated: 14 days
Frozen: Unacceptable
Methodology
Next Generation Sequencing
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Mon; Report available: 5 days
Reference Range
Not detected
Clinical Significance
WT1 mutations occur in up to 15% of patients with AML. Cytogenetically normal acute myeloid leukemia (CN-AML) is the largest subgroup of AML, which represents approximately 45% of adult patients with AML. A WT1 mutation at diagnosis is associated with poor, outcome; it independently predicts a higher risk of relapse when other molecular markers with established prognostic significance and clinical variables are taken into consideration.
Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
33608 Ortega Highway |
San Juan Capistrano, CA 92675-2042 |