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Chromosome Analysis and Alpha-Fetoprotein with Reflex to AchE and Fetal Hgb, Amniotic Fluid [14591Z]
Test Code14591
CPT Codes
88235, 88267, 88280, 82106<br><strong>This test is for non-New York patient testing. For New York patient testing use test code 17581X</strong>
Physician Attestation of Informed Consent
This germline genetic test requires physician attestation that patient consent has been received if ordering medical facility is located in AK, DE, FL, GA, IA, MA, MN, NV, NJ, NY, OR, SD or VT or test is performed in MA.
Includes
If the amniotic fluid AFP MoM is ≥2.0, then Acetylcholinesterase and Fetal Hemoglobin by ID will be performed at an additional charge (CPT code(s): 82664, 83033).
Preferred Specimen
20 mL amniotic fluid collected in a sterile screw-cap container
Minimum Volume
5 mL
Instructions
30 mL is preferred if other testing, e.g., microarray, FISH, is ordered.
Ship at room temperature. Do not freeze.
Send all tubes to lab (supernatant for AFP will be split by cytogenetics lab).
Please contact the laboratory Genetic Counselor at 1-866-GENEINFO (1-866-436-3463) with any questions.
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.
If sample exceeds stability, please call laboratory at ext. 4307 for instructions.
Ship at room temperature. Do not freeze.
Send all tubes to lab (supernatant for AFP will be split by cytogenetics lab).
Please contact the laboratory Genetic Counselor at 1-866-GENEINFO (1-866-436-3463) with any questions.
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.
If sample exceeds stability, please call laboratory at ext. 4307 for instructions.
Transport Temperature
Room temperature
Specimen Stability
Room temperature: Preferred
Refrigerated: Acceptable
Frozen: Unacceptable
Refrigerated: Acceptable
Frozen: Unacceptable
Methodology
Culture • Karyotype • Microscopy
AFP: Immunoassay (IA) • Gel Electrophoresis • Immunodiffusion (ID)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Daily; Report available: 9-12 days (additional days for reflex if needed)
Reference Range
See Laboratory Report
Clinical Significance
This test will detect chromosome abnormalities of the fetus including numerical, structural, and mosaic abnormalities. Chromosome analysis will also reveal fetal sex and sex chromosome abnormalities. Indications for prenatal chromosome analysis may include advanced maternal age, abnormal fetal ultrasound, abnormal maternal serum screen, abnormal cell-free DNA results, history of a previous child with a chromosome abnormality, or a parent who carries a balanced chromosomal rearrangement or has another chromosome abnormality.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153