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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Cholinesterase, Plasma
Test Code335
CPT Codes
82480
Preferred Specimen
1 mL plasma collected in an EDTA (lavender-top) tube
Minimum Volume
0.5 mL
Instructions
Draw a lavender-top (EDTA) tube of whole blood. Spin tube to separate plasma. Pour plasma into plastic aliquot tube and refrigerate until shipping. Ship plasma sample refrigerated. Do not send packed cells. Do not send one tube of whole blood.
Plasma cholinesterase results are not accurate if plasma sample is not separated from RBC's in a timely manner (within 1 hour). Hemolyzed plasma samples are not acceptable. Hemolysis can lead to apparent increases in plasma cholinesterase activity, and could mask an enzyme deficiency.
Plasma cholinesterase results are not accurate if plasma sample is not separated from RBC's in a timely manner (within 1 hour). Hemolyzed plasma samples are not acceptable. Hemolysis can lead to apparent increases in plasma cholinesterase activity, and could mask an enzyme deficiency.
Transport Container
Plastic screw-cap vial
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 21 days
Refrigerated: 21 days
Frozen: 30 days
Refrigerated: 21 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis
Methodology
Kinetic Spectrophotometric (KS)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Mon-Fri; Report available: Next day
Limitations
Results may be depressed in patients who consume oral contraceptives. Hepatic disease may cause up to a 70% decrease in enzyme levels. Cholinesterase may be slightly elevated in patients with obesity or diabetes.
Reference Range
Male | 3334-7031 IU/L | |
Female | 2504-6297 IU/L |
Clinical Significance
Approximately 1 in every 2500 individuals has inherited defective or deficiency of the enzyme (pseudocholinesterase) that metabolizes succinylcholine (an anesthetic agent). With "normal" dosage, these individuals have prolonged apnea. Such individuals are responsive at much smaller concentrations of this anesthetic agent than the general population. Low concentrations of pseudocholinesterase are observed in individuals exposed to organophosphorous insecticides and patients with hepatic dysfunction.
Performing Laboratory
Quest Diagnostics Nichols Institute |
14225 Newbrook Drive |
Chantilly, VA 20153 |