|
|
| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Beta-2-Glycoprotein I Antibodies (IgG, IgM)
Test Code91244
CPT Codes
86146 (x2)
Preferred Specimen
2 mL plasma collected in a 3.2% sodium citrate (light blue-top) tube
Minimum Volume
1 mL
Other Acceptable Specimens
Serum
Instructions
Please note: If test is ordered as part of a profile or panel, then the profile or panel transport temperature applies.
Plasma: Centrifuge light blue-top tube 15 minutes at approximately 1500 g within 60 minutes of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial. Plasma must be free of platelets (<10,000/mcL).
Plasma: Centrifuge light blue-top tube 15 minutes at approximately 1500 g within 60 minutes of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial. Plasma must be free of platelets (<10,000/mcL).
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 5 days
Refrigerated: 14 days
Frozen: 30 days
Refrigerated: 14 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic
Methodology
Immunoassay (IA)
Setup Schedule
Set up: Mon-Sat; Report available: 3-4 days
Reference Range
| B2 Glycoprotein I (IgG) Ab | <20.0 U/mL |
| B2 Glycoprotein I (IgM) Ab | <20.0 U/mL |
Clinical Significance
Beta-2-Glycoprotein 1 (also known as apolipoprotein H), is a cofactor in antiphospholipid antibody binding and is the critical antigen in the antiphospholipid antibody syndrome. The presence of high titer IgG/IgM beta-2-glycoprotein 1 antibodies is one criteria for the diagnosis of antiphospholipid antibody syndrome.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153
