Myelin Basic Protein

Test Code
663

CPT Codes
83873

Preferred Specimen
1 mL CSF submitted in a sterile, plastic leak-proof CSF tube

Minimum Volume
0.5 mL

Instructions
Do not centrifuge CSF. Refrigerate CSF and send refrigerated (cold packs) or freeze CSF specimens -20°C or lower and send frozen samples on dry ice to the laboratory. Blood contamination and hemolysis may interfere with results.
CSF must be clear. Submitting 4th lumbar puncture collection tube minimizes blood contamination.

Transport Temperature
Refrigerated (cold packs)

Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 21 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Xanthochromia/RBCs/hemolysis in CSF

Methodology
Radioimmunoassay (RIA)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule
Set up: Mon, Thurs evening: Report available: 3-7 days

Limitations
The pesence of myelin basic protein in the spinal fluid is supportive evidence for the diagnosis of multiple sclerosis and other demyelinating diseases, although it is a non-specific finding and present in other causes of damage to CNS myelin.

Reference Range
2.0-4.0 mcg/L Negative
4.1-6.0 mcg/L Weakly positive
>6.0 mcg/L Positive


Clinical Significance
The concentration of MBP is often increased in patients with demyelinating diseases such as multiple sclerosis and may be increased in patients with head injury, CNS trauma, tumor, stroke, and viral encephalitis.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153




The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.