Glypican 3, IHC with Interpretation

Test Code

CPT Codes

Preferred Specimen
Formalin-fixed, paraffin-embedded tissue block

Other Acceptable Specimens
3 unstained, positively charged slides

Please include surgical pathology report.

Transport Container
IHC Specimen Transport Kit

Transport Temperature
Room temperature

Specimen Stability
Room temperature: Indefinitely
Refrigerated: Indefinitely
Frozen: Unacceptable


Setup Schedule
Set up: Mon-Fri; Report available: 3 days

Reference Range
Interpretive report

Clinical Significance
Glypican 3 (GPC3) is most commonly used in the differential diagnosis of hepatocellular carcinoma (HCC) or hepatoblastoma, which overexpress GPC3, as opposed to cirrhotic liver or other non-neoplastic liver lesions. Embryonal germ cell tumor and Wilms tumor also overexpress glypican 3.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.