11-Deoxycortisol, LC/MS/MS [30543X]

Test Code

CPT Codes

Preferred Specimen
1 mL serum collected in a red-top tube (no gel)

Minimum Volume
0.25 mL

Other Acceptable Specimens
Plasma collected in: EDTA (lavender-top), or EDTA (royal blue-top), or Sodium heparin (green-top) or, Lithium heparin (green-top)

Separate serum after clotting. Ship serum refrigerated or frozen. Do not submit glass tubes. An early morning specimen is preferred.

Transport Container
Plastic screw-cap vial

Transport Temperature

Specimen Stability
Room temperature: 4 days
Refrigerated: 4 days
Frozen: 28 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Serum Separator Tube (SST®) • Glass tube

Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

Setup Schedule
Set up: Tues night, Fri evening; Report available: 2 days

Reference Range
Adult Male    
18-29 Years ≤119 ng/dL
30-39 Years ≤135 ng/dL
40-49 Years ≤76 ng/dL
50-59 Years ≤42 ng/dL
Adult Female    
18-29 Years ≤107 ng/dL
30-39 Years ≤51 ng/dL
40-49 Years ≤62 ng/dL
50-66 Years ≤37 ng/dL
1-12 Months 10-200 ng/dL
1-4 Years  7-210 ng/dL
5-9 Years ≤122 ng/dL
10-13 Years ≤245 ng/dL
14-17 Years ≤302 ng/dL
Premature (31-35 Weeks) ≤235 ng/dL
Term  ≤170 ng/dL
Tanner Stages    
II-III Males  11-150 ng/dL
II-III Females  15-130 ng/dL
IV-V Males 14-120 ng/dL
IV-V Females  17-120 ng/dL

Clinical Significance
11-Deoxycortisol (Compound S) is useful in diagnosing patients with 11-beta-hydroxylase deficiency (second leading cause of congenital adrenal hyperplasia) and primary (adrenal failure) or secondary (hypothalamic-pituitary ACTH deficiency) adrenal insufficiency.

Performing Laboratory
Quest Diagnostics Nichols Inst San Juan Capistrano
33608 Ortega Highway
San Juan Capistrano, CA 92675

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.