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BK Virus DNA, Quantitative, Real-Time PCR, Urine
Test Code16581
CPT Codes
87799
Preferred Specimen
4.3 mL random urine submitted in a cobas® PCR Media tube
Minimum Volume
4.3 mL
Instructions
Neat urine must be immediately stabilized by transferring to a cobas® PCR Media tube.
Liquid level must be between the black fill lines on the cobas® PCR Media tube label window.
Liquid level must be between the black fill lines on the cobas® PCR Media tube label window.
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 90 days
Refrigerated: 90 days
Frozen: Unacceptable
Refrigerated: 90 days
Frozen: Unacceptable
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Under-or over-filled cobas® PCR urine sample tubes • Neat urine
Methodology
Real-Time Polymerase Chain Reaction
Setup Schedule
Set up: Daily; Report available: 1 day
Reference Range
| BK Virus DNA, QN PCR | Not Detected (IU/mL) |
| BK Virus DNA, QN PCR | Not Detected (Log IU/mL) |
Clinical Significance
This test detects and quantitates BK Virus DNA in urine specimens of kidney transplant recipients who are at risk of developing BKV-associated nephropathy (BKVAN) and associated hemorrhagic cystitis leading to kidney failure. Prospective viral load monitoring of BKV DNA in urine (and plasma) is useful to exclude a diagnosis of BKVAN and to monitor the course of BKV infection. The assay is calibrated to the First World Health Organization International Standard for BKV DNA with a Reportable Range of 200-100,000,000 IU/mL (2.30-8.00 log IU/mL).
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153
