Adenosine Deaminase, Pleural Fluid

Test Code
17696

CPT Codes
84311

Preferred Specimen
0.5 mL pleural fluid submitted in a sterile, plastic leak-proof container

Minimum Volume
0.1 mL

Transport Temperature
Frozen

Specimen Stability
Room temperature: 24 hours
Refrigerated: 72 hours
Frozen: 6 months

Methodology
Kinetic Spectrophotometric (KS)

FDA Status
This test was performed using a kit that has ot been cleared or approved by the FDA. The analytical performance characteristics of this test have been determined by Quest Diagnostics. This test should not be used for diagnosis without confirmation by other medically established means.

Setup Schedule
Set up: Mon-Sat a.m.; Report available: Next day

Reference Range
ADA, Pleural Fluids  < 9.2 U/L 

Tuberculosis                       mean 92.1 U/L
Metastatic malignancies  mean 23.3 U/L
Mesotheliomas                  mean 34.9 U/L
Pulmonary embolism       mean 23.8 U/L
Lymphoma                          mean 64.3 U/L


Clinical Significance
An elevated level of adenosine deaminase (AD) in human serum, plasma or select body fluids is used as a surrogate marker for inflammation or infectious disease. In CSF, pleural effusions, and pericardial fluid in particular, elevated AD activity has been shown to be associated with tubercular lesions. Additional disease states that may result in elevated AD activity include liver cirrhosis, liver fibrosis, certain malignancies (e. g. lymphoma), viral hepatitis, and autoimmune diseases (e. g. SLE,  rheumatoid arthritis).

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153




The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.