Myeloperoxidase Antibody

Test Code
8796

CPT Codes
86021

Preferred Specimen
1 mL serum

Minimum Volume
0.3 mL

Transport Container
Plastic screw-cap vial

Transport Temperature
Room temperature

Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis

Methodology
Immunoassay (IA)

Setup Schedule
Set up: Tues-Sat a.m.; Report available: Next day

Limitations
Approximately 90% of patients with a P-ANCA pattern by IFA have myeloperoxidase-specific antibodies.

Reference Range
<1.0 AI No antibody detected 
≥1.0 AI Antibody detected 


Clinical Significance
Patients with vascular diseases will generally have either a C-ANCA pattern or P-ANCA pattern, and give positive results in specific tests for PR-3 or MPO. Patients with bowel disease have been shown to have antibodies that give a P-ANCA or C-ANCA pattern. These antibodies, however, may not be directed toward MPO. Patients with drug induced lupus, etc., often present with a P-ANCA pattern that is associated with antibodies against MPO.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153




The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.