Myeloperoxidase Antibody

Test Code
8796

CPT Codes
86021

Preferred Specimen
1 mL serum

Minimum Volume
0.3 mL

Transport Container
Plastic screw-cap vial

Transport Temperature
Room temperature

Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis

Methodology
Immunoassay (IA)

Setup Schedule
Set up: Tues-Sat a.m.; Report available: Next day

Limitations
Approximately 90% of patients with a P-ANCA pattern by IFA have myeloperoxidase-specific antibodies.

Reference Range
<1.0 AI No antibody detected 
≥1.0 AI Antibody detected 


Clinical Significance
Autoimmune vasculitis diseases are characterized by abnormal immune responses that result in inflammation and necrosis of blood vessels. The immune dysfunction may be triggered by infection, autoimmune disease, or exposure to a drug; often the cause is unknown. ANCA-associated vasculitis diseases are often characterized by the size of the blood vessels involved. The diseases present with diverse clinical features and are often rapidly progressive, causing irreversible injury to the vessels of the organs affected, such as the kidneys and lungs.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153




The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.