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Ganglioside Antibody Panel 6
Test Code90131
CPT Codes
83520 (x6)
Includes
Ganglioside GM-1 Antibodies (IgG, IgM), EIA
Ganglioside GD1a Antibody (IgG, IgM), EIA
Ganglioside Asialo-GM-1 Antibody (IgG, IgM), EIA
Ganglioside GD1a Antibody (IgG, IgM), EIA
Ganglioside Asialo-GM-1 Antibody (IgG, IgM), EIA
Preferred Specimen
2 mL serum
Patient Preparation
Overnight fasting is preferred
Minimum Volume
1 mL
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 24 hours
Refrigerated: 7 days
Frozen: 30 days
Refrigerated: 7 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received room temperature
Setup Schedule
Set up: Mon, Wed; Report Available: 5-10 days
Reference Range
See Laboratory Report
Clinical Significance
The presence of antibodies to the gangliosides GM1, Asialo-GM1, and GD1a has been associated with motor neuropathies. High titers of antibody to GM1 are most typical of multifocal motor neuropathy; however, antibodies to other gangliosides are often present. In most cases, anti-ganglioside antibodies are IgM class. IgG antibodies have been reported less often, generally associated with acute conditions. Many reports have found increased anti-asialo-GM1 antibody titers in patients with multifocal motor neuropathy, lower motor neuron disease, or motor neuropathy with or without multifocal block, Guillain-Barré Syndrome, and amyotrophic lateral sclerosis. There may be a relationship between titers of asialo-GM1 antibodies and clinical status in individual patients. In some lower motor neuron disorders, improvement in strength has occurred after therapeutic reduction in anti-asialo-GM1 antibody titers.
Performing Laboratory
Quest Diagnostics Nichols Inst San Juan Capistrano
33608 Ortega Highway
San Juan Capistrano, CA 92690-6130