Zinc Protoporphyrin (ZPP)

Test Code

CPT Codes

Preferred Specimen
2 mL whole blood collected in an EDTA (lavender-top) tube - protect from light

Minimum Volume
0.5 mL

Other Acceptable Specimens
Whole blood collected in light-protected: EDTA (royal blue-top) tube, sodium heparin (royal blue-top) tube, sodium heparin (green-top) tube, sodium heparin lead-free (tan-top) tube, or potassium EDTA (tan-top) tube

Use a lead-free tube if a blood lead is also requested. Specimen should be foil wrapped. Protect from light.

Transport Temperature
Room temperature

Specimen Stability
Room temperature: 4 days
Refrigerated: 10 days
Frozen: Unacceptable

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis • Received frozen • Clotted


FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule
Set up: Mon-Sat; Report available: 1 day

Aluminum and anemia of chronic disease may cause elevated results.

Reference Range
 < 100 mcg/dL

Clinical Significance
Zinc protoporphyrin (ZPP) accumulates in erythrocytes as a result of chronic lead absorption or iron deficiency anemia.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.