Chromosome Analysis, Tissue with Reflex to Microarray, ClariSure® Oligo-SNP

Test Code

CPT Codes
88233, 88262

If Chromosome Analysis result is "Tissue has no growth", then Chromosomal Microarray, POC, ClariSure® Oligo-SNP will be performed at an additional charge (CPT code(s): 81229).

Preferred Specimen
5x5 mm tissue collected in a sterile container in Hanks', Ringer's solution or culture medium with antibiotics

Minimum Volume
2x3 mm

Tissue sample minimum 2x3 mm in culture medium with antibiotics or in a sterile container with Hanks', Ringer's or saline solution.

Transport Temperature
Room temperature

Specimen Stability
Room temperature: Preferred
Refrigerated: Acceptable
Frozen: Unacceptable
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.

Culture • Karyotype • Microscopy

Setup Schedule
Chromosome reports 14 days/Micro-array 10 days if needed

Reference Range
See Laboratory Report

Clinical Significance
Chromosome analysis of products of conception (POC) can detect fetal chromosome abnormalities that are associated with approximately one-half of all first trimester spontaneous abortions. Since chromosome analysis on products of conception has an increased failure rate, this test will reflex to chromosomal microarray if chromosome analysis fails. Chromosomal microarray (CMA) detects aneuploidies, deletions and duplications below the resolution of chromosome analysis (karyotyping), and long continuous regions of homozygosity.

Performing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92675-2042

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.