Creatine Kinase Isoenzymes (CK Isoenzymes) with Total CK [4451]

For Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.

Test Code

Alias/See Also
CK Isoenzyme Panel;
CPK Fractionated;
CPK Isoenzymes

CPT Codes
82550, 82552

CK-BB, CK-MB, CK-MM and Creatine Kinase (CK), Total

Preferred Specimen
2 mL Frozen Serum

Minimum Volume
1 mL

If CK and CK Isoenzymes are ordered together, specimen must be submitted frozen.

Transport Container
Plastic screw-cap vial

Transport Temperature

Specimen Stability
Room temperature: Unacceptable Refrigerated: 48 hours Frozen: 14 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis • Received thawed

Electrophoresis • Enzymatic

Setup Schedule
Set up: Sun-Fri evening; Report available: 2-3 days

Reference Range
See Laboratory Report

Clinical Significance
Test is for myocardial infarction and skeletal muscle damage. Elevated results may be due to myocarditis, myocardial infarction (heart attack), muscular dystrophy, muscle trauma, or excessive exercise.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

Last Updated: November 29, 2021

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.