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RET (10q11), FISH, Tissue
MessageFor Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.
Test Code
RETF
Alias/See Also
Non-small cell lung cancer (NSCLC)
CPT Codes
88271x2, 88291 – DNA probe, each (first probe set), Interpretation and report 88271x2 – DNA probe, each; each additional probe set (if appropriate) 88271x1 – DNA probe, each; coverage for sets containing 3 probes (if appropriate) 88271x2 – DNA probe, each; coverage for sets containing 4 probes (if appropriate) 88271x3 – DNA probe, each; coverage for sets containing 5 probes (if appropriate) 88274 w/modifier 52 – Interphase in situ hybridization, <25 cells, each probe set (if appropriate) 88274 – Interphase in situ hybridization, 25 to 99 cells, each probe set (if appropriate) 88275 – Interphase in situ hybridization, 100 to 300 cells, each probe set (if appropriate)
Preferred Specimen
Formalin-fixed, paraffin-embedded (FFPE) tumor tissue block. Blocks prepared with alternative fixation methods may be acceptable; provide fixation method used.
Minimum Volume
Two consecutive, unstained, 5 micron-thick sections placed on positively charged slides, and 1 hematoxylin and eosin-stained slide.
Other Acceptable Specimens
Slides: Four consecutive, unstained, 5 micron-thick sections placed on positively charged slides, and 1 hematoxylin and eosin-stained slide.
Transport Temperature
Ambient
Specimen Stability
Room Temperature: N/A
Refrigerated: N/A
Frozen: UNACCEPTABLE
Refrigerated: N/A
Frozen: UNACCEPTABLE
Methodology
Fluorescence In Situ Hybridization (FISH)
Clinical Significance
Identifying RET gene rearrangements in patients with late-stage, lung adenocarcinomas that are negative for EGFR mutations and ALK rearrangements
Performing Laboratory
MAYO CLINIC LABORATORIES
200 FIRST ST
ROCHESTER, MN 55905
Last Updated: November 19, 2021
