CNS, Demyelinating Disease Eval, Serum

Message
For Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.


Test Code
CNSDD


Alias/See Also
Mayo Code CDS1


CPT Codes
86255x2, 86256x2 if appropriate

Preferred Specimen
3 mL Serum from a Red Top tube


Patient Preparation
Patient Preparation: For optimal antibody detection, we recommend drawing the specimen before initiation of immunosuppressant medication.

Minimum Volume
2 mL


Other Acceptable Specimens
Serum from a SST


Instructions
Allow blood to clot. Centrifuge and transfer serum to a plastic vial.


Transport Container
Plastic vial


Transport Temperature
Refrigerated


Specimen Stability
Room Temperature: 72 Hours
Refrigerated: 28 Days
Frozen: 28 Days


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis, gross lipemia, gross icterus


Methodology
Flow Cytometry

Setup Schedule
Monday, Tuesday, Thursday


Report Available
7 - 10 days


Clinical Significance
Diagnosis of inflammatory demyelinating diseases (IDDs) with similar phenotype to neuromyelitis optica spectrum disorder (NMOSD), including optic neuritis (single or bilateral) and transverse myelitis

Diagnosis of autoimmune myelin oligodendrocyte glycoprotein (MOG)-opathy

Diagnosis of neuromyelitis optica (NMO) Distinguishing NMOSD, acute disseminated encephalomyelitis (ADEM), optic neuritis, and transverse myelitis from multiple sclerosis early in the course of disease


Performing Laboratory
MAYO CLINIC LABORATORIES
200 FIRST ST
ROCHESTER, MN 55905


Last Updated: November 19, 2021


The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.