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CNS, Demyelinating Disease Eval, Serum
MessageFor Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.
Test Code
CNSDD
Alias/See Also
Mayo Code CDS1
CPT Codes
86053, 86363, 86053-Titer (if appropriate 86363-Titer (if appropriate)iate),
Preferred Specimen
3 mL Serum from a Red Top tube
Patient Preparation
Patient Preparation: For optimal antibody detection, we recommend drawing the specimen before initiation of immunosuppressant medication.
Minimum Volume
2 mL
Other Acceptable Specimens
Serum from a SST
Instructions
Allow blood to clot. Centrifuge and transfer serum to a plastic vial.
Transport Container
Plastic vial
Transport Temperature
Refrigerated
Specimen Stability
Room Temperature: 72 Hours
Refrigerated: 28 Days
Frozen: 28 Days
Refrigerated: 28 Days
Frozen: 28 Days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis, gross lipemia, gross icterus
Methodology
Flow Cytometry
Setup Schedule
Monday, Tuesday, Thursday
Report Available
7 - 10 days
Clinical Significance
Diagnosis of inflammatory demyelinating diseases (IDDs) with similar phenotype to neuromyelitis optica spectrum disorder (NMOSD), including optic neuritis (single or bilateral) and transverse myelitis
Diagnosis of autoimmune myelin oligodendrocyte glycoprotein (MOG)-opathy
Diagnosis of neuromyelitis optica (NMO) Distinguishing NMOSD, acute disseminated encephalomyelitis (ADEM), optic neuritis, and transverse myelitis from multiple sclerosis early in the course of disease
Diagnosis of autoimmune myelin oligodendrocyte glycoprotein (MOG)-opathy
Diagnosis of neuromyelitis optica (NMO) Distinguishing NMOSD, acute disseminated encephalomyelitis (ADEM), optic neuritis, and transverse myelitis from multiple sclerosis early in the course of disease
Performing Laboratory
MAYO CLINIC LABORATORIES
200 FIRST ST
ROCHESTER, MN 55905
Last Updated: February 2, 2023
