Total Glutathione

For Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.

TLGLUT

10 mL Whole Blood collected in ACD Solution A or B tube. Send Whole Tube

Solution A: 8.5mL draw;
Solution B: 6mL draw

Ship refrigerated on ice packs. Do not place specimens directly on ice packs

ACD A or B Tube

Refrigerated

Room Temperature: Unacceptable
Refrigerated: 21 days
Frozen: Unacceptable

Specimens received room temperature or frozen. Hemolyzed specimens. Samples oversaturated with ACD solution

3 Days

Glutathione is a tripeptide formed by a peptide linkage between the amine group of cysteine linked to glycine and the carboxyl group of the glutamate side-chain. It is an abundant cellular reducing agent, whose major biological function is mitigating oxidative damage to biological macromolecules. Glutathione is also important in the metabolism and excretion of xenobiotic compounds. Glutathione is consumed to maintain cells in a reduced condition. Consequently, glutathione levels in patient samples are expected to be diminished in disease states where oxygen reactive species are involved, such as rheumatoid arthritis and atherosclerosis. Low glutathione levels have been linked to reduced dopamine production in neurons, which suggests a relationship to dopamine based neurological disorders such as Parkinson’s disease. High levels of glutathione have been linked to chemotherapy resistance in cancer treatments.