Histoplasma Antibody, Complement Fixation, Serum

Message

For Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.

Test Code

HISTCF

Alias/See Also

938

CPT Codes
86317 (x2)

Includes

Yeast Phase Antibody and Mycelial Phase Antibody

Preferred Specimen

1 mL serum

Minimum Volume

0.5 mL

Instructions

For CSF, use test code 5297- Histoplasma Antibody, Complement Fixation, CSF

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis • Grossly icteric

Methodology
Complement Fixation (CF)

Setup Schedule

Set up: Tues-Sat; Report available: 2-5 days

Reference Range

Yeast Phase Ab	<1:8 titer
Mycelial Phase Ab	<1:8 titer

Interpretive Criteria

<1:8	Antibody Not Detected
≥1:8	Antibody Detected

Clinical Significance

This test is used for the diagnosis and prognosis of histoplasma infections. Titers ≥1:32 are highly suggestive of H. capsulatum infection. The CF test is more frequently positive with sera from chronic active pulmonary histoplasmosis than sera from primary active pulmonary disease.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

Last Updated: May 30, 2024

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.