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Coccidioides Antibody, Complement Fixation, CSF [5295X]
MessageFor Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.
Test Code
COCCD
CPT Codes
86635
Preferred Specimen
1 mL CSF collected in a sterile plastic leak-proof CSF container
Minimum Volume
0.2 mL
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days
Refrigerated: 14 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly icteric
Methodology
Complement Fixation (CF)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Tues-Sat; Report available: 2-5 days
Limitations
False-negatives may occur in patients with solitary pulmonary lesions. Patients with active histoplasmosis may generate cross reactions. Elevated serum antibodies may be present in patients with meningeal coccidiocomycosis.
Reference Range
<1:1 titer
Interpretive Criteria| <1:1 | Antibody Not Detected |
| ≥1:1 | Antibody Detected |
Clinical Significance
Infection by Coccidioides immitis can produce a spectrum of disease with most patients being asymptomatic and some developing disseminated disease including pneumonia and meningitis. C. immitis meningitis is associated with a mononuclear pleocytosis.
Performing Laboratory
| Quest Diagnostics Nichols Institute |
| 14225 Newbrook Drive |
| Chantilly, VA 20153 |
Last Updated: November 29, 2021
