Alkaline Phosphatase

Message

For Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.

Test Code

ALKPHS

CPT Codes
84075

Preferred Specimen

1 mL serum collected in a serum separator tube (SST)

Minimum Volume

0.5 mL

Other Acceptable Specimens

Plasma collected in: Sodium heparin (green-top) tube or lithium heparin (green-top) tube

Instructions

Administration of STRENSIQ may interfere in certain assays and may falsely elevate values. For patients receiving STRENSIQ, consideration should be given to using alternate methods.

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 7 days
Refrigerated: 7 days
Frozen: 28 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Anticoagulants other than heparin

Methodology
Spectrophotometry (SP)

Setup Schedule

Set up: Daily; Report available: Next day

Reference Range

	Male (U/L)	Female (U/L)
0-6 Days	46-245	46-245
7-14 Days	69-306	69-306
15 Days-<1 Month	113-412	113-412
1-5 Months	104-450	104-450
6-11 Months	100-334	100-334
1-9 Years	117-311	117-311
10 Years	128-396	128-396
11 Years	125-428	100-429
12 Years	123-426	69-296
13 Years	100-417	58-258
14 Years	78-326	51-179
15 Years	65-278	45-150
16 Years	56-234	41-140
17-19 Years	46-169	36-128
20-49 Years	36-130	31-125
>49 Years	35-144	37-153

Clinical Significance

Serum alkaline phosphatase levels are of interest in the diagnosis of hepatobiliary disorders and bone disease associated with increased osteoblastic activity. Moderate elevations of alkaline phosphatase may be seen in several conditions that do not involve the liver or bone. Among these are Hodgkin's disease, congestive heart failure, ulcerative colitis, regional enteritis, and intra-abdominal bacterial infections. Elevations are also observed during the third trimester of pregnancy.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

Last Updated: November 24, 2021

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.