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Aldosterone, LC/MS/MS
MessageFor Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.
Test Code
ALDOSS
CPT Codes
82088
Preferred Specimen
1 mL serum collected in a red-top tube (no gel)
Minimum Volume
0.25 mL
Other Acceptable Specimens
Plasma collected in: EDTA (lavender-top) tube, sodium heparin or lithium heparin (green-top) tube
Instructions
Serum separator tubes are unacceptable. Draw blood in a no-additive (red-top) tube. Separate serum after clotting. Draw "upright" samples at least 1/2 hour after patient sits up.
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 4 days
Refrigerated: 7 days
Frozen: 28 days
Refrigerated: 7 days
Frozen: 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Moderate to gross hemolysis • Serum separator tube (SST)
Methodology
Chromatography/Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Mon-Sat; Report available: 3-5 days
Limitations
Aldosterone concentration varies based on body position and sodium intake. 24-hour urine specimens for aldosterone are an alternative.
Reference Range
Adult | |
Upright 8:00-10:00 am | ≤28 ng/dL |
Upright 4:00-6:00 pm | ≤21 ng/dL |
Supine 8:00-10:00 am | 3-16 ng/dL |
Pediatric | |
1-12 months** | 2-70 ng/dL |
1-4 years** | 2-37 ng/dL |
5-9 years | ≤9 ng/dL |
10-13 years | ≤21 ng/dL |
14-17 years | ≤35 ng/dL |
Infants | |
Premature (31-35 weeks)** | ≤144 ng/dL |
Term** | ≤217 ng/dL |
Tanner Stages** | |
II-III Males | 1-13 ng/dL |
II-III Females | 2-20 ng/dL |
IV-V Males | 3-14 ng/dL |
IV-V Females | 4-32 ng/dL |
**Pediatric data from J Clin Endocrinol Metab. 1992;75:1491 and J CLin Endocrinol Metab. 1989; 69;1133-1136.
Clinical Significance
Approximately 1-2% of individuals with primary hypertension have primary hyperaldosteronism characterized by hypokalemia (low potassium) and low direct renin. Because serum aldosterone concentrations vary due to dietary sodium intake and body positions, some physicians prefer measurement of 24-hour urine concentrations for aldosterone.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153
Last Updated: November 24, 2021