Dementia Autoimmune Evaluation, Serum

Message

For Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.

Test Code

DMS2

CPT Codes
86255 x 18;86341--83519-ARBI (if appropriate) 84182-AGNBS (if appropriate) 86255-AINCS (if appropriate) 86256-AMPIS (if appropriate) 84182-AMIBS (if appropriate) 84182-AN1BS (if appropriate) 84182-AN2BS (if appropriate) 84182-CRMWS (if appropriate) 86255-DPPCS (if appropriate) 86256-DPPTS (if appropriate) 86256-GABIS (if appropriate) 86255-GFACS (if appropriate) 86256-GFATS (if appropriate) 86255-IG5CS (if appropriate) 86256-IG5TS (if appropriate) 86255-GL1CS (if appropriate) 86256-GL1TS (if appropriate) 86255-NFHCS (if appropriate) 86256-NIFTS (if appropriate) 86255-NFLCS (if appropriate) 86256-NMDIS (if appropriate) 84182-PC1BS (if appropriate) 86255-PCABP (if appropriate) 84182-PCTBS (if appropriate)

Preferred Specimen

4 mL serum from a red top tube

Minimum Volume

2.5 mL

Other Acceptable Specimens

Serum from an SST

Instructions

Centrifuge red top tube, transfer serum to a pour off tube.

Transport Container

pour off tube

Transport Temperature

Refrigerated

Specimen Stability

Room Temperature: 72 hours
Refrigerated: 28 days
Frozen: 28 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis, gross lipemia, gross icterus

Methodology
Indirect Immunofluorescence Assay (IFA),
Cell-Binding Assay (CBA),
Western Blot (WB),
Immunoblot (IB),
Radioimmunoassay (RIA)

Setup Schedule

Monday - Sunday

Report Available

10 - 13 days

Clinical Significance

Investigating new onset dementia and cognitive impairment plus 1 or more of the following accompaniments using cerebrospinal fluid specimens: -Rapid onset and progression -Fluctuating course -Psychiatric accompaniments (psychosis, hallucinations) -Movement disorder (myoclonus, tremor, dyskinesias) -Headache -Autoimmune stigmata (personal history or family history or signs of diabetes mellitus, thyroid disorder, vitiligo, poliosis [premature graying], myasthenia gravis, rheumatoid arthritis, systemic lupus erythematosus) -Smoking history (20+ pack years) or other cancer risk factors -History of cancer -Inflammatory cerebrospinal fluid -Neuroimaging findings atypical for degenerative etiology.

Performing Laboratory
Mayo Clinic Laboratories
200 First Street SW
Rochester, MN 55905

Last Updated: November 19, 2021

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.