Dementia Autoimmune Evaluation, CSF

Message

For Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.

Test Code

DMC2

CPT Codes
86255 x18;86341 x1--84182 AGNBC (if appropriate) 86255 AINCC (if appropriate) 86256 AMPIC (if appropriate) 84182 AMIBC (if appropriate) 84182 AN1BC (if appropriate) 84182 AN2BC (if appropriate) 84182 CRMWC (if appropriate) 86255 DPPCC (if appropriate) 86256 DPPTC (if appropriate) 86256 GABIC (if appropriate) 86255 GFACC (if appropriate) 86256 GFATC (if appropriate) 86255 IG5CC (if appropriate) 86256 IG5TC (if appropriate) 86255 GL1CC (if appropriate) 86256 GL1TC (if appropriate) 86255 NFHCC (if appropriate) 86256 NIFTC (if appropriate) 86255 NFLCC (if appropriate) 86256 NMDIC (if appropriate) 84182 PC1BC (if appropriate) 84182 PCTBC (if appropriate) 86255 PCA1C (if appropriate)

Preferred Specimen

4 mL CSF in a sterile vial

Minimum Volume

2 mL

Instructions

Transfer CSF to a sterile vial using a sterile pipette

Transport Container

Sterile Vial

Transport Temperature

Refrigerated

Specimen Stability

Room Temperature: 72 hours
Refrigerated: 28 days
Frozen: 28 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis, gross lipemia, gross icterus

Methodology
Indirect Immunofluorescence Assay (IFA),
Cell-Binding Assay (CBA),
Western Blot (WB),
Immunoblot (IB),
Radioimmunoassay (RIA)

Setup Schedule

Monday - Sunday

Report Available

8 - 11 days

Clinical Significance

Investigating new onset dementia and cognitive impairment plus 1 or more of the following accompaniments using cerebrospinal fluid specimens: -Rapid onset and progression -Fluctuating course -Psychiatric accompaniments (psychosis, hallucinations) -Movement disorder (myoclonus, tremor, dyskinesias) -Headache -Autoimmune stigmata (personal history or family history or signs of diabetes mellitus, thyroid disorder, vitiligo, poliosis [premature graying], myasthenia gravis, rheumatoid arthritis, systemic lupus erythematosus) -Smoking history (20+ pack years) or other cancer risk factors -History of cancer -Inflammatory cerebrospinal fluid -Neuroimaging findings atypical for degenerative etiology.

Performing Laboratory
Mayo Clinic Laboratories
200 First Street SW
Rochester, MN 55905

Last Updated: November 19, 2021

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.