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Test CodeADENOF
CPT Codes
84311
Preferred Specimen
0.5 mL pleural fluid submitted in a sterile, plastic leak-proof container
Minimum Volume
0.1 mL
Transport Temperature
Frozen
Specimen Stability
Room temperature: 24 hours
Refrigerated: 72 hours
Frozen: 6 months
Refrigerated: 72 hours
Frozen: 6 months
Methodology
Kinetic Spectrophotometric (KS)
FDA Status
This test was performed using a kit that has ot been cleared or approved by the FDA. The analytical performance characteristics of this test have been determined by Quest Diagnostics. This test should not be used for diagnosis without confirmation by other medically established means.
Setup Schedule
Set up: Mon-Sat a.m.; Report available: Next day
Reference Range
| Adenosine Deaminase, Pleural Fluid | <9.2 U/L |
| Tuberculosis | mean 92.1 U/L |
| Metastatic malignancies | mean 23.3 U/L |
| Mesotheliomas | mean 34.9 U/L |
| Pulmonary embolism | mean 23.8 U/L |
| Lymphoma | mean 64.3 U/L |
Clinical Significance
An elevated level of adenosine deaminase (AD) in human serum, plasma or select body fluids is used as a surrogate marker for inflammation or infectious disease. In CSF, pleural effusions, and pericardial fluid in particular, elevated AD activity has been shown to be associated with tubercular lesions. Additional disease states that may result in elevated AD activity include liver cirrhosis, liver fibrosis, certain malignancies (e. g. lymphoma), viral hepatitis, and autoimmune diseases (e. g. SLE, rheumatoid arthritis).
Performing Laboratory
| Quest Diagnostics Nichols Institute |
| 14225 Newbrook Drive |
| Chantilly, VA 20153 |
Last Updated: November 24, 2021
