Parietal Cell Antibody, ELISA

Message
For Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.


Test Code
APARI


CPT Codes
83516

Preferred Specimen
1 mL serum


Minimum Volume
0.3 mL


Other Acceptable Specimens
1 mL Serum (Min0.3 mL)
SST Glass; Refrigerated;
-OR-
1 mL Serum (Min0.3 mL)
SST Plastic; Refrigerated;


Instructions
Collect 1 mL serum from a red top (no additive) tube and place in a sterile, plastic, screw cap vial. Serum separator tube, plastic or glass is also accepted. Ship refrigerated (cold packs) only.


Transport Temperature
Refrigerated (cold packs)


Specimen Stability
Room temperature: 8 hours
Refrigerated: 14 days
Frozen: 30 days


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Lipemia


Methodology
Immunoassay  (IA)

Setup Schedule
Tuesday, Thursday, Saturday Afternoon
Report available: Next Day


Reference Range
≤20.0 U Negative
20.1-24.9 U    Equivocal
≥25.0 U Positive


Clinical Significance

Gastric Parietal Cell Antibodies are found in 90% of patients with pernicious anemia. They are also found in autoimmune chronic atrophic gastritis preceding pernicious anemia. The antigenic target is the H+/K+ ATPase gastric proton pump responsible for parietal cell acid generation in the stomach.



Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153


Last Updated: December 3, 2021


The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.