Neuromyelitis Optica (NMO)/Aquaporin-4-IgG Fluorescence-Activated Cell Sorting (FACS) Assay, Serum

Message

For Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.

Test Code

NMOFS

Alias/See Also

NMO (Neruomyelitis Optica)
NMO-IgG
AQP4
Aquaporin
Devic's Antibody
Transverse Myelitis Antibody
Optic Neuritis Antibody
Vision Loss Antibody

CPT Codes
86053; 86053- NMO/AQP4-IgG FACS titer (if appropriate)

Preferred Specimen

3 mL Serum Red Top tube

Minimum Volume

2 mL serum

Other Acceptable Specimens

3 mL serum SST

Instructions

Centrifuge Red Top tube, Aliquot serum to a pour off tube

Transport Container

Pour off tube

Transport Temperature

Refrigerated

Specimen Stability

Room Temperature: 72 hours
Refrigerated: 28 days
Frozen: 28 days

Methodology
Flow Cytometry

Setup Schedule

Monday, Tuesday, Thursday

Report Available

5 - 8 days

Limitations

AQP4-IgG antibodies may drop below detectable levels in setting of therapies for acute attack (IV methylprednisolone or plasmapheresis) or attack prevention (immunosuppressants).

Clinical Significance

Diagnosis of a neuromyelitis optica spectrum disorder (NMOSD)
Diagnosis of autoimmune AQP4 channelopathy
Diagnosis of neuromyelitis optica (NMO)
Distinguishing NMOSD from multiple sclerosis early in the course of disease

Performing Laboratory
Mayo Clinic Laboratories
200 First Street SW
Rochester, MN 55905

Last Updated: February 9, 2023

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.