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First Trimester Screen, Hyperglycosylated hCG (h-hCG)
MessageFor Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.
Test Code
HYPHCG
CPT Codes
81508<br> Not for California Clients. For New York patient testing, use test 16969
Includes
PAPP-A (Pregnancy-associated Plasma Protein), h-hCG (hyperglycosylated hCG), risk calculation which includes NT (Nuchal Translucency)
Preferred Specimen
1.5 mL serum
Minimum Volume
0.8 mL
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 14 days
Refrigerated: 14 days
Frozen: 28 days
Refrigerated: 14 days
Frozen: 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Moderate and gross hemolysis • Lipemia
Methodology
Chemiluminescence (CL) • Immunoassay (IA)
FDA Status
This test was performed using a kit that has not been cleared or approved by the FDA. The analytical performance characteristics of this test have been determined by Quest Diagnostics. This test should not be used for diagnosis without confirmation by other medically established means.
Setup Schedule
A.M. Sets up 6 days a week.
Limitations
First Trimester Screen results consistent with increased risk of trisomy should be confirmed with CVS or amniotic fluid specimen. Maternal serum screening yields a low percentage of false negatives. A wide range of other chromosomal abnormalities are not identified by maternal serum screening.
Reference Range
| MSS Down Syndrome Risk | <1:270 |
| MSS Risk for Trisomy 18 Risk | <1:100 |
Clinical Significance
To screen for Down syndrome and trisomy 18 at 9.0-13.9 weeks gestation.
Performing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92690-6130
Last Updated: November 29, 2021
