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FISH, APL, PML/RARA, Translocation 15, 17
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Test Code
PMLRAR
CPT Codes
88271 (x2), 88275
Preferred Specimen
5 mL whole blood or 3 mL bone marrow collected in a sodium heparin (green-top) tube or EDTA (lavender-top) tube
Minimum Volume
3 mL whole blood • 1 mL bone marrow
Other Acceptable Specimens
Whole blood collected in: Sodium heparin (royal blue-top) tube or sodium heparin lead-free (tan-top) tube • Bone marrow collected in: Bone marrow transport tube (available upon request), sodium heparin (royal blue-top) tube, or sodium heparin lead-free (tan-top) tube
Instructions
Bone marrow 1-3 mL or whole blood 3-5 mL collected in a sodium heparin tube
Transport Temperature
Room temperature
Specimen Stability
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.
Methodology
Fluorescence in situ Hybridization (FISH)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
A.M. Sets up 7 days a week.
Report Available
Reports in 2 to 3 days.
Reference Range
See Laboratory Report
Clinical Significance
This test is performed to detect the PML-RARA fusion, t(15;17), by FISH (fluorescence in situ hybridization). This assay is useful for diagnosis and monitoring of acute promyelocytic leukemia.
Performing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92675-2042
Last Updated: November 29, 2021
