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FISH, Myeloma, Chromosomes CEP 9, 11, 15
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Test Code
MYELCH
CPT Codes
88271(x3), 88275
Preferred Specimen
3 mL bone marrow collected in a sodium heparin (green-top) tube
Minimum Volume
1 mL
Other Acceptable Specimens
Sodium heparin (royal blue-top) tube • Sodium heparin lead-free (tan-top) tube
Transport Temperature
Room temperature
Specimen Stability
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not Reject.
Methodology
Fluorescence in situ Hybridization (FISH)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Daily; Report available: 7 days
Reference Range
See Laboratory Report
Clinical Significance
Plasma Cell Myeloma (PCM) is characterized by the proliferation of malignant monoclonal plasma cells in the bone marrow. Hyperdiploidy with gains of odd numbered chromosomes, including 9, 11, and 15, has been associated with a more favorable outcome in myeloma patients. This test replaces FISH, Multiple Myeloma (5, 9, 15), which is no longer available.
Performing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92675-2042
Last Updated: November 29, 2021