Cyanide, Blood [400]

For Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.

Test Code

Alias/See Also

CPT Codes

Preferred Specimen
10 mL whole blood collected in a sodium heparin (green-top) tube

Minimum Volume
1 mL

Other Acceptable Specimens
6 mL whole blood collected in: EDTA (lavender-top) tube, or sodium fluoride (gray-top) tube

Transport Temperature
Refrigerated (cold packs)

Specimen Stability
Room temperature: 14 days
Refrigerated: 14 days
Frozen: 30 days


FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule
Set up: Daily a.m.; Report available: 2 days

Reference Range
<0.1 mg/L

Clinical Significance
Toxic syndromes are rapid and include flushing, headache,
dizziness, and tachypnea that may progress to respiratory
depression and death. 80% of cyanide is converted to
thiocyanate. Administration of sodium nitroprusside
contributes to the total body pool of cyanide and
complicates interpretation.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

Last Updated: November 29, 2021

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.