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Centromere IgG Antibody
MessageFor Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.
Test Code
ACMT
Alias/See Also
76078;
Centro;
CENP-A;
CENP-B
Centro;
CENP-A;
CENP-B
CPT Codes
86235
Preferred Specimen
1 mL Serum SST (speckled top or gold top) tube
Minimum Volume
0.5 mL Serum
Instructions
SST or Red top; Avoid hemolysis. Invert a minimum of 5 times, then allow to clot in an upright position for 30 minutes. Centrifuge the tube for at least 10 minutes. Keep tightly stoppered.
Transport Container
Room Temperature or Refrigerated (preferred)
Specimen Stability
Room Temperature = 1 day
Refrigerated = 5 days
Frozen = at least 5 days
Refrigerated = 5 days
Frozen = at least 5 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Grossly hemolized or lipemic specimens
Methodology
EIA (Enzyme Immunoassay)
Setup Schedule
Monday - Wednesday - Friday
BS
BS
Report Available
4 days
Clinical Significance
ENZYME LINKED IMMUNOSORBENT IMMUNOASSAY (ELISA). CENTROMERE ANTIBODIES ARE RECOGNIZED AS A SEROLOGICAL MARKER OF A FORM OF SYSTEMIC SCLEROSIS OR SCLERODERMA THAT IS COMMONLY REFERRED TO AS CREST SYNDROME. PATIENTS WITH CENTROMERE ANTIBODIES TEND TO HAVE A MORE BENIGN FORM OF SCLERODERMA WITH LESS SYSTEMIC INVOLVEMENT AND THESE PATIENTS TEND TO PRODUCE NO OTHER ANTINUCLEAR ANTIBODIES INCLUDING SCL-70
Performing Laboratory
CompuNet Clinical Laboratories, LLC
2308 Sandridge Drive
Moraine, OH 45439
Last Updated: May 9, 2022
