Sjogren's Antibodies

Message

For Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.

Test Code

SSASSB

Alias/See Also

7832;
Anti-RO Anti-LA;
Sjogrens;
Sjogrens Antibodies;
Sjogrens Antibody;
SSA Antibody;
SSA / SSB;
SSB Antibody;

CPT Codes
86235(2)

Includes

Includes SS-A and SS-B

Preferred Specimen

1 mL serum (minimum 0.5 mL)

Instructions

SST or Red top: Avoid hemolysis. Invert a minimum of 5 times, then allow to clot in an upright position for 30 minutes. Centrifuge the the tube for at least 10 minutes. Keep tightly stoppered.

Transport Container

SST (speckled top), Red top , Plastic Vial (transfer) tube

Transport Temperature

Refrigerated (preferred)

Specimen Stability

Room Temperature = n/a
Refrigerated = 5 days
Frozen = at least 7 days

Methodology
EIA

Setup Schedule

Even days of the week (Monday - Friday only) 7:00 am
BS

Report Available

3 days

Reference Range

	SEX	AGE	Report Normals
Sjogrens Antibodies (SSA)	N/M/F	1000Y	< 20 = Negative
			> = 20 = Positive
	Values between 20 and 40 are weak positives and repeat testing is recommended in 3 - 6 months
Sjogrens Antibodies (SSB)	N/M/F	1000Y	<20 = Negative
			> = 20 = Positive
	Values between 20 and 40 are weak positives and repeat testing is recommended in 3 - 6 months
	Antibodies to SSA (RO) and SSB (LA) are observed with the highest frequency in Sjogren"s Syndrome, although these antibodies are also found in a significant percentage of patients with SLE.

Clinical Significance

Sjögren's antibodies (SS-B) is detected in approximately 15% of patients with Sjögren's Syndrome. Sjögren's antibody (SS-B) is present only if Sjögren's antibody (SS-A) is also detected. The presence of both antibodies (SS-A and SS-B) strengthen the diagnosis of Sjögren's Syndrome and conveys prognostic information.

Performing Laboratory
CompuNet Clinical Laboratories, LLC
2308 Sandridge Drive
Moraine, OH 45439

Last Updated: November 23, 2021

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.