Lactate, Plasma

For Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.

LAC

70252;
Blood Lactate;
Lactate;
L-Lactate;

3 mL Na Fluoride K Oxalate tube (grey top) tube (minimum 0.5 mL). Centrifuge and separate plasma from cells - send plasma only for testing

Specimens must be obtained without the use of a tourniquet or immediately after the tourniguet has been applied. Patients should avoid exercise of the hand or arm immediately before and during the procedure. 2 mL refrigerated plasma. Collect in chillded tube, remove plasma from the cells within 15 minutes, and place plasma in clean transport tube on an ice slurry. Plasma may also be frozen. Keep tightly stoppered.

The assay manufacturer advises: "we have become aware of an interference which may lead to falsely low recovery with assays that use the Trinder methodology when a patient blood sample is taken while elevated levels of N-acetyl-p-benzoquinone imine (NAPQI, a metabolite of Acetaminophen), N-acetylcysteine (NAC), and/or Metamizole are still present. The half-life may be increased by 80% when hepatic impairment is present as may occur with acetaminophen overdose. Therefore, the Roche medical officers have indicated that absorption and metabolism of drugs is patient specific, and resumption of testing must be left to the discretion of the treating physician.”

Sodium Fluoride K Oxalate (grey top) tube

Plasma in ice Slurry. Plasma may be frozen

Room Temperature = 8 hours if plasma is separated from cells within 15 minutes
Refrigerated = 14 days if plasma is separated from cells within 15 minutes.
Frozen = 38 days if plasma is separated from cells within 15 minutes and specimen was collected in a Na-fluoride/Na-hepatin tube  

Hemolysis, Lipemia, incorrect specimen type, insufficient sample volume, improper storage conditions, exceeds specimen stability guidelines, contaminated sample.

24/7
MVCHEM

1 hour from receipt

SEX	AGE	Report Normals	Units
N/M/F	133Y	0.5 - 2.2	MMOL/L

Lactic acid is the endproduct of the anaerobic metabolism of glucose. The blood lactic acid concentration is affected by its production in muscle cells and erythrocytes and its rate of metabolism in the liver. During exercise, blood lactate can increase up to ten times of normal levels.