RPR w/ Reflex Titer

For Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.

Test Code

Alias/See Also
Rapid PL Reagin;
RPR Card;
Syphilis Serology Screen (blood); 

CPT Codes

Preferred Specimen
2 mL serum (minimum 0.5 mL) 

SST or Red top: Avoid hemolysis. Invert a minimum of 5 times, then allow to clot in an upright position for 30 minutes. Centrifuge the the tube for at least 10 minutes. Keep tightly stoppered.

Transport Container
SST (speckled top), Red top , Plastic Vial (transfer) tube

Transport Temperature

Specimen Stability
Room Temperature = 1 day
Refrigerated = 5 days
Frozen = at least 7 days


Setup Schedule
Monday - Wednesday - Friday

Report Available
1 day

Reference Range
SEX AGE Report Normals
N/M/F 133Y Non-Reactive 

Clinical Significance
This is a non-treponemal screening test for syphilis. False positive results may occur due to systemic lupus erythematosus, malaria, mononucleosis, infectious hepatitis, leprosy, brucellosis, atypical pneumonia, typhus, yaws, pinta, or pregnancy. Positive results should be confirmed with a more specific treponema pallidum antibody test (FTA-ABS). Monitoring of RPR is helpful in assessing effectiveness of therapy.

Performing Laboratory
CompuNet Clinical Laboratories, LLC
2308 Sandridge Drive
Moraine, OH 45439

Last Updated: November 23, 2021

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.