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Lysozyme (Muramidase) [619]
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Test Code
LYSOZM
Alias/See Also
619
CPT Codes
85549
Preferred Specimen
1 mL serum
Minimum Volume
0.5 mL
Instructions
Centrifuge serum specimens within 1 hour of collection. Transfer serum to sterile, plastic, screw-cap vial. Delayed separation of the serum can result in spuriously high levels of lysozyme, presumably because of the breakdown of leukocytes.
Transport Container
Plastic screw-cap vial
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 24 hours
Refrigerated: 15 days
Frozen: 18 days
Refrigerated: 15 days
Frozen: 18 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Room temperature samples older than 24 hours • Plasma collected in citrate or heparin • Moderate to gross hemolysis • Grossly lipemic
Methodology
Enzymatic
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Mon-Sat a.m.; Report available: Next day
Reference Range
5.0-11.0 mcg/mL
Clinical Significance
Lysozyme in the serum is primarily due to the degradation of granulocytes and monocytes and its concentration reflects the turnover of these cells. Increases are seen in benign and malignant processes. Serum lysozyme is elevated in patients with acute or chronic granulocytic or monocytic leukemias and levels decrease with successful treatment. Conversely, patients with lymphocytic leukemia may have depressed plasma lysozyme levels.
Performing Laboratory
| Quest Diagnostics Nichols Institute |
| 14225 Newbrook Drive |
| Chantilly, VA 20153 |
Last Updated: November 30, 2021
