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Myeloperoxidase Antibody [8796]
MessageFor Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.
Test Code
MYELOP
Alias/See Also
8796
CPT Codes
86021
Preferred Specimen
1 mL serum
Minimum Volume
0.3 mL
Instructions
Avoid hemolysis.
Transport Container
Plastic screw-cap vial
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days
Refrigerated: 14 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis
Methodology
Immunoassay (IA)
Setup Schedule
Set up: Tues-Sat a.m.; Report available: Next day
Limitations
Approximately 90% of patients with a P-ANCA pattern by IFA have myeloperoxidase-specific antibodies.
Reference Range
| <1.0 AI | No antibody detected |
| ≥1.0 AI | Antibody detected |
Clinical Significance
Autoimmune vasculitis diseases are characterized by abnormal immune responses that result in inflammation and necrosis of blood vessels. The immune dysfunction may be triggered by infection, autoimmune disease, or exposure to a drug; often the cause is unknown. ANCA-associated vasculitis diseases are often characterized by the size of the blood vessels involved. The diseases present with diverse clinical features and are often rapidly progressive, causing irreversible injury to the vessels of the organs affected, such as the kidneys and lungs.
Performing Laboratory
| Quest Diagnostics Nichols Institute |
| 14225 Newbrook Drive |
| Chantilly, VA 20153 |
Last Updated: November 30, 2021
