A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Myelin Basic Protein [663]

Message
For Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.


Test Code
MBP


Alias/See Also
663


CPT Codes
83873

Preferred Specimen
1.2 mL CSF collected in a sterile CSF collection tube #4


Minimum Volume
0.5 mL


Instructions
Do not centrifuge CSF. Refrigerate CSF and send refrigerated (cold packs) or freeze CSF specimens -20 degrees C or lower and send frozen samples on dry ice to the laboratory.

Blood contamination and hemolysis may interfere with results. CSF must be clear. Submitting 4th lumbar puncture collection tube minimizes blood contamination.


Transport Temperature
Frozen


Specimen Stability
Room temperature 7 days
Refrigerated 14 days
Frozen 21 days


Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
xanthochromia/RBCs/hemolysis in CSF


Methodology
Radioimmunoassay

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule
Monday, Thursday


Report Available
3 - 7 days


Limitations
The pesence of myelin basic protein in the spinal fluid is supportive evidence for the diagnosis of multiple sclerosis and other demyelinating diseases, although it is a non-specific finding and present in other causes of damage to CNS myelin.


Reference Range
≤4.0 mcg/LNegative
4.1-6.0 mcg/LWeakly positive
>6.0 mcg/LPositive


Clinical Significance
The concentration of MBP is often increased in patients with demyelinating diseases such as multiple sclerosis and may be increased in patients with head injury, CNS trauma, tumor, stroke, and viral encephalitis.


Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153



Last Updated: November 30, 2021


The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.