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Carbamazepine, Free [18948]
MessageFor Specimen Integrity during Extreme Weather see the “Lockbox Usage in Extreme Weather” document at the top of this page.
Test Code
CARBMF
Alias/See Also
18948
CPT Codes
80157
Preferred Specimen
2 mL serum collected in a red-top tube (no gel)
Minimum Volume
1.2 mL
Other Acceptable Specimens
Plasma collected in: EDTA (lavender-top) tube or sodium heparin (green-top) tube
Transport Container
Plastic screw-cap vial
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 14 days
Refrigerated: 14 days
Frozen: 10 months
Refrigerated: 14 days
Frozen: 10 months
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Serum separator tube (SST)
Methodology
Chromatography/Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Mon-Sat a.m.; Report available: 2 days
Reference Range
1.0-3.0 mcg/mL
Clinical Significance
Carbamazepine and its metabolite (10,11- Carbamazepine epoxide) are widely used for control of generalized tonic-clonic, partial-onset, complex and mixed seizure disorders. The metabolism of carbamazepine in epileptic patients has several different pathways that can be altered when the patient is co-medicated with other anticonvulsants and, therefore, its therapeutic level should be monitored along with its metabolite in their free and protein bound states.
Performing Laboratory
| Quest Diagnostics Nichols Institute |
| 14225 Newbrook Drive |
| Chantilly, VA 20153 |
Last Updated: November 24, 2021
