A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Follicular Lymphoma, BCL-2/JH t(14;18), Real-Time PCR, Cell-based
Test CodeBCL2JH
Alias/See Also
15007
CPT Codes
81278<br />
Preferred Specimen
5 mL whole blood or bone marrow collected in an EDTA (lavender-top) tube
Minimum Volume
1 mL
Other Acceptable Specimens
Formalin-fixed, paraffin-embedded tissue block • Fresh (unfixed) tissue submitted in RPMI or in formalin fixative
Instructions
Fresh frozen tissue (acceptable): stable for approximately 1 year at -70ºC.
Fresh (unfixed) tissue in RPMI or tissue in formalin fixative (acceptable): Ship at room temperature or refrigerated. Identify what fixative or medium is used and write it on the sample container.
Fresh (unfixed) tissue in RPMI or tissue in formalin fixative (acceptable): Ship at room temperature or refrigerated. Identify what fixative or medium is used and write it on the sample container.
Transport Temperature
Room temperature
Specimen Stability
Whole blood and bone marrow
Room temperature: 7 days
Refrigerated: 14 days
Frozen: Unacceptable
Paraffin Block
Room temperature: Indefinitely
Refrigerated: Unacceptable
Fro
Room temperature: 7 days
Refrigerated: 14 days
Frozen: Unacceptable
Paraffin Block
Room temperature: Indefinitely
Refrigerated: Unacceptable
Fro
Methodology
Real-Time Polymerase Chain Reaction
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Tues, Sat; Report available: 4 days
Reference Range
Negative
Clinical Significance
Follicular lymphoma is the most common type of non-Hodgkin's lymphoma in the United States. Up to 90% of follicular lymphomas carry BCL-2/JH t(14;18) (q32;Q21) chromosome translocation. The presence of the BCL-2 translocation has been associated with poor prognosis in one group of diffuse large-cell and follicular lymphoma patients. Analysis of BCL-2 translocations provides an important marker for detection and monitoring of malignancy during patient treatment and follow up.
Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
33608 Ortega Highway |
San Juan Capistrano, CA 92675-2042 |
Last Updated: December 20, 2023